NEUROBIOLOGY OF DISEASE文献大全第12页

Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons.
abstract：:Novel anti-oxidants based on the buckminsterfullerene molecule were explored as neuroprotective agents in cortical cell cultures exposed to excitotoxic and apoptotic injuries. Two polyhydroxylated C60 derivatives, C60(OH)n, n = 12, and C60(OH)nOm, n = 18-20, m = 3-7 hemiketal groups, demonstrated excellent anti-oxidan...

journal_title：Neurobiology of disease

pub_type： 杂志文章

doi：10.1006/nbdi.1996.0013

authors： Dugan LL,Gabrielsen JK,Yu SP,Lin TS,Choi DW

更新日期：1996-04-01 00:00:00
Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.
abstract：:Patients with trisomy 21 [Down syndrome (DS)] progressively develop amyloid beta-protein (A beta) deposits and then other features of Alzheimer's disease (AD), apparently due to increased gene dosage and thus expression of the beta-amyloid precursor protein. Because the neuropathological phenotype in older DS subjects...

journal_title：Neurobiology of disease

pub_type： 杂志文章

doi：10.1006/nbdi.1996.0003

authors： Lemere CA,Blusztajn JK,Yamaguchi H,Wisniewski T,Saido TC,Selkoe DJ

更新日期：1996-02-01 00:00:00
Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions.
abstract：:Possible roles of the complement (C) system in the normal and injured brain were explored with inbred mice that carried a frameshift mutation in the C5 gene. A congenic pair was used: the C5-sufficient (C5+) B10.D2/nSnJ strain with the functional allele (Hc1) from the C57BL/10J donor strain was compared with the C5-de...

journal_title：Neurobiology of disease

pub_type： 杂志文章

doi：10.1006/nbdi.1996.0020

authors： Pasinetti GM,Tocco G,Sakhi S,Musleh WD,DeSimoni MG,Mascarucci P,Schreiber S,Baudry M,Finch CE

更新日期：1996-01-01 00:00:00
Identification of a unique apolipoprotein E allele in Microcebus murinus; ApoE brain distribution and co-localization with beta-amyloid and tau proteins.
abstract：:This report is devoted to the characterization of the apolipoprotein E (ApoE) in Microcebus murinus. Only one allele homologous to the human ApoE4 allele was evidenced. The distribution of the corresponding ApoE protein in the brain was found in association with the pathological proteins characteristic of Alzheimer's ...

journal_title：Neurobiology of disease

pub_type： 杂志文章

doi：10.1006/nbdi.1995.0018

authors： Calenda A,Jallageas V,Silhol S,Bellis M,Bons N

更新日期：1995-06-01 00:00:00
Tardive dyskinetic syndrome in rats infected with Borna disease virus.
abstract：:Tardive Dyskinesia (TD) is a hyperkinetic movement disorder caused by chronic treatment of psychiatric patients with dopamine (DA) receptor blocking drugs (Stacy & Jankovic 1991). Although TD is one of the most important and frequently encountered iatrogenic disorders in clinical medicine, its pathophysiology is poorl...

journal_title：Neurobiology of disease

pub_type： 杂志文章

doi：10.1006/nbdi.1994.0014

authors： Solbrig MV,Koob GF,Fallon JH,Lipkin WI

更新日期：1994-12-01 00:00:00
Infection of sympathetic and sensory neurones with herpes simplex virus does not elicit a shut-off of cellular protein synthesis: implications for viral latency and herpes vectors.
abstract：:Infection of non-neuronal cell types with herpes simplex virus type 1 (HSV-1) results in the degradation of host mRNA (Kwong & Frenkel 1987) and a shutoff in host protein synthesis (Roizman et al. 1965). This effect is mediated by a virion associated protein that is encoded by the viral vhs gene (Read & Frenkel 1983)....

journal_title：Neurobiology of disease

pub_type： 杂志文章

doi：10.1006/nbdi.1994.0011

authors： Nichol PF,Chang JY,Johnson EM Jr,Olivo PD

更新日期：1994-11-01 00:00:00

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